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Postdoctoral researcher in biochemistry - helsinki
/Helsinki , Null, Finland/

Postdoctoral Researcher with strong knowledge in metabolism, enzymology or bioenergetics. Our goal is to access the methanogen-specific Wood-Ljungdahl pathway for the conversion of CO2 to multi-carbon fuels and chemicals. To achieve our goals, we unravel metabolic principles and enzyme function in anaerobic archaea, and we apply synthetic biology to create useful pathways and enzymes. Research is carried out at our excellent facilities at Aalto University, School of Chemical Engineering. The laboratories are situated on the main campus of Aalto University in Otaniemi (short metro-ride from Helsinki) within the Department of Bioproducts and Biosystems. Job description The project may be adjusted according to the talents and preferences of the applicants. Most experiments will be performed in anaerobic chambers with enzymes purified from wild-type methanogens or from genetically engineered strains. Tasks are: Study new archaeal enzymes and elucidate their reaction mechanisms In vitro pathway design in order to study the bioenergetics/thermodynamics Simulations for synthetic metabolic pathways Possible projects also involve synthesis of substrate analogues, electrochemistry, or advanced spectroscopic methods (NMR, EPR). Requirements PhD in a suitable field, such as biochemistry, protein research, organic chemistry, or theoretical chemistry with the desire for some laboratory work Be highly committed to science and strive for excellence Develop own smart ideas and think independently Be able to focus on solving tough scientific problems Have good written and oral communication skills in English Skills, knowledge or interest in some of the following areas are highly appreciated: Enzymology, protein purification Metabolic modelling and thermodynamics Spectroscopic methods (HPLC, NMR, EPR, Electrochemistry) Elucidation of reaction mechanisms Organic chemistry/synthesis

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